Completed Projects

Projects completed by the Biomarkers Consortium include:

Project Name/Committee RESULTS
Osteoarthritis Biomarkers Project [IISC] Established predictive validity and assessed the responsiveness of imaging and biochemical markers for knee osteoarthritis, Completion: Q2 2015
AD Targeted Cerebrospinal Fluid (CSF) Proteomics Project [NSC] Explored the initial validation of a multiplexed panel of known biomarkers, examined BACE levels and enzymatic activity and set up initial validation of a mass spectroscopy panel using AD cerebrospinal fluid samples from ADNI, Completion: Q2 2015
AD/Mild Cognitive Impairment (MCI) Placebo Data Analysis Project [NSC] Analyzed AD and MCI placebo data from ~40 large industry clinical trials to provide better measures of cognition and disease progression, Completion: Q2 2015
Sarcopenia Consensus Summit [MDSC] Generated the first evidence-based definition of sarcopenia and specific guidelines for clinical diagnosis and regulatory evaluation of treatments, Completion: July 2013
Carotid MRI Reproducibility Project [MDSC] Established a standardized carotid MRI protocol and determined the impact of site/platform on reproducibility, Completion: July 2013
PET Radioligand Project [NSC] Developed improved, more sensitive PET radioligands with higher binding to the peripheral benzodiazepine receptor, Completion: December 2012
Alzheimer’s Disease (AD) Targeted Plasma Proteomics Project [NSC] Explored the initial validation of a multiplexed panel of known AD plasma-based biomarkers using plasma samples from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) plasma, Completion: July 2012
Adiponectin Project [MDSC] Established the utility of adiponectin as a predictive biomarker of glycemic control, Completion: June 2009